tag:blogger.com,1999:blog-9008122866340502585.post3771369643940610117..comments2024-03-24T05:50:07.033-07:00Comments on Biologizing: Progress in Future Treatment Options for DepressionPeter Houlihanhttp://www.blogger.com/profile/00961900865379520219noreply@blogger.comBlogger8125tag:blogger.com,1999:blog-9008122866340502585.post-12566882415577644872015-02-08T21:10:59.081-08:002015-02-08T21:10:59.081-08:00That makes a lot more sense, thanks for the explan...That makes a lot more sense, thanks for the explanation.John Slepchuknoreply@blogger.comtag:blogger.com,1999:blog-9008122866340502585.post-31010788651318319422015-02-08T16:05:01.433-08:002015-02-08T16:05:01.433-08:00Thank you Rebecca! To answer your question I go to...Thank you Rebecca! To answer your question I go to this study: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2833107/ which says: "The use of active coping strategies such as problem solving and planning has been linked to improved well-being and a greater capacity to handle stressful situations in diverse populations, ranging from trauma-exposed to medically ill individuals. Active coping with stress requires an individual to face their fears, and resilient individuals exhibit lower levels of denial, avoidant coping behaviour and behavioural disengagement(Feder A. et al 2009)." There are many therapy and help groups out there that can help individuals deal with their stresses in positive ways like mentioned before. Websites such as DailyStrength.org are out there. DailyStrength is a site that has forums where people can ask questions and seek help with their depression. But other than support groups, lots of exercise, healthy eating and life choices along with yoga and other outlets for stress do help a lot to manage depression.<br />-Ashley Condon<br />Works Cited:<br />Feder, A., Nestler, E. J., & Charney, D. S. (2009). Psychobiology and molecular genetics of resilience. Nat Rev Neurosci, 10(6), 446-457. doi:10.1038/nrn2649Anonymoushttps://www.blogger.com/profile/14712536713769085475noreply@blogger.comtag:blogger.com,1999:blog-9008122866340502585.post-29347072548650145842015-02-08T15:26:43.999-08:002015-02-08T15:26:43.999-08:00Thank you for your question John. You can think of...Thank you for your question John. You can think of the cation-mediated current like a scale to show the activity of the VTA and DA neurons. The higher the current, the more active those neurons are. Researchers originally believed that higher activity of this region of the brain after stress indicated depression; maybe because the brain is over reactive to negative stimuli compared to a 'normal brain' that would not react as much in response to the stimuli. However, the results of their study showed that this thinking was completely backward. The 'depressed' mice showed low activity in response to stress where the 'normal' mice showed increased activity. They found this interesting because it showed that they were wrong in their previous understanding of these neurons, meaning further study is required. Once these neurons are understood, future medicine could potentially design a drug that could safely change these abnormalities in depressive brains and help those suffering with depression.<br />-Ashley CondonAnonymoushttps://www.blogger.com/profile/14712536713769085475noreply@blogger.comtag:blogger.com,1999:blog-9008122866340502585.post-32418876093175593232015-02-08T12:26:19.851-08:002015-02-08T12:26:19.851-08:00This was a great post though I was confused by you...This was a great post though I was confused by your explanation of Science Magazine's study, " The study expected to find that the hyperpolarization-activated cation channel–mediated current (Ih) of these neurons would normalize after a stress response in the resilient mice. However, they actually found that it showed an increase of this current as well as increased K+ channel currents in the ventral tegmental area (VTA) dopamine (DA) neurons of the brain in the resilient mice". Not many of my classes have delved into neurophysiology, can you explain why the researchers expected this result and why what they found was surprising? John Slepchuknoreply@blogger.comtag:blogger.com,1999:blog-9008122866340502585.post-79988478699138104122015-02-06T15:27:55.209-08:002015-02-06T15:27:55.209-08:00You did a really great job describing the biologic...You did a really great job describing the biological mechanisms of depression. Hopefully those who suffer from this debilitating neurological disorder will have better treatment options available as medical science advances.<br /><br />I feel it is worth mentioning the benefits of exercise on preventing or helping to lessen the effects of depression. Regular exercise is great for an individual's mental health, as walking or running daily can enhance moods and has been correlated with feeling better mentally.<br /><br />Great post!<br /><br />- Michael SalhanyAnonymousnoreply@blogger.comtag:blogger.com,1999:blog-9008122866340502585.post-2065246064038128692015-02-06T12:21:46.184-08:002015-02-06T12:21:46.184-08:00I agree with this comment in that environmental fa...I agree with this comment in that environmental factors could have been mentioned more in relation to causes of depression. Especially when a traumatic event happens, how would that change someone's brain chemistry? But, I loved reading about a stride in the right direction to discovering a new treatment for a disease that affects so many people.<br /><br />-Carolyn McDonaghAnonymousnoreply@blogger.comtag:blogger.com,1999:blog-9008122866340502585.post-43900261307025962032015-02-05T21:25:40.630-08:002015-02-05T21:25:40.630-08:00Outstanding job on your discussion of biological f...Outstanding job on your discussion of biological factors that play into depression. I think it would have also been interesting to briefly mention some environmental factors associated with depression, since a good deal of research has shown that both biological and environmental factors can lead to mental health issues. <br /><br />Posted by: Amanda OkpoeboAmanda Okpoebohttps://www.blogger.com/profile/15732641493240595246noreply@blogger.comtag:blogger.com,1999:blog-9008122866340502585.post-11570917384103757082015-02-05T18:12:20.366-08:002015-02-05T18:12:20.366-08:00Awesome post. You really made all the neuroscience...Awesome post. You really made all the neuroscience that seems bulky in textbooks understandable and applicable to your topic. What other kinds of treatment options are most common for people who may not be fans of taking medication prescribed by doctors or traditional scientific therapies?Anonymoushttps://www.blogger.com/profile/16383544017374714833noreply@blogger.com