tag:blogger.com,1999:blog-9008122866340502585.post716580866284631050..comments2024-03-24T05:50:07.033-07:00Comments on Biologizing: Self-Assembling 3D Cancer VaccinePeter Houlihanhttp://www.blogger.com/profile/00961900865379520219noreply@blogger.comBlogger8125tag:blogger.com,1999:blog-9008122866340502585.post-44691493201325319212015-02-15T16:02:03.284-08:002015-02-15T16:02:03.284-08:00Basically, the scaffolding hold antigens of the ca...Basically, the scaffolding hold antigens of the cancer cells that the dendritic cells would normally recognize on the surface of the tumor. As well as the antigen, it holds chemical compounds that attract these immune cells. By having a large volume of these antigens present in one place it helps the immune response happen faster. These dendritic cells are temporarily "attracted, housed, and reprogrammed" to work with the immune system against the cancer. Other vaccines that don't have the scaffold present are short-lived because they don't have this longer-term environment to prolong the differentiation process of the dendritic cells. All these factors help contribute to a much stronger immune response than normally observed with other cancer vaccines. <br /><br />-Carolyn McDonagh Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-9008122866340502585.post-48650046409164070432015-02-13T19:48:11.877-08:002015-02-13T19:48:11.877-08:00Super interesting! I really liked your use of diag...Super interesting! I really liked your use of diagrams in your blog post - it made the concepts easier to understand for readers who might not have a background in the subject. I was wondering if they had done research to see whether this immunotherapy works better on some types of cancers or not. I know that cancer patients can sometimes become immunocompromised and injecting a vaccine that induces a strong immune response might not work as well for those patients. Thanks!<br /><br /><br />-Rebecca QuirieAnonymoushttps://www.blogger.com/profile/16383544017374714833noreply@blogger.comtag:blogger.com,1999:blog-9008122866340502585.post-9635645165223187852015-02-13T17:34:13.612-08:002015-02-13T17:34:13.612-08:00Posted by Phi DuongPosted by Phi DuongAnonymousnoreply@blogger.comtag:blogger.com,1999:blog-9008122866340502585.post-78104887608714146522015-02-13T17:33:52.111-08:002015-02-13T17:33:52.111-08:00This is a very interesting concept of treating can...This is a very interesting concept of treating cancer. The procedure was explained very clearly above. Just for curiosity, do you know if this immunotherapy improve the immune system in general afterwards or it only improves the adaptive system, which consists of dendritic cells only? Is this treatment applicable to all cancers? And is chemotherapy still required during this treatment? Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-9008122866340502585.post-52082037949511173352015-02-13T14:49:08.299-08:002015-02-13T14:49:08.299-08:00This is really a great advancement in modern medic...This is really a great advancement in modern medicine but is there any estimated time frame until we can actively use this research? Do we use this therapy in anything yet or is this purely in the research phase?<br />-Dan Staiculescu Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-9008122866340502585.post-25010112787818788492015-02-13T14:21:44.670-08:002015-02-13T14:21:44.670-08:00This is a really cool approach to cancer treatment...This is a really cool approach to cancer treatment. Is it known why the scaffolding provokes a stronger immune response?<br />-Daniel BonkowskiAnonymousnoreply@blogger.comtag:blogger.com,1999:blog-9008122866340502585.post-745205656259069572015-02-10T07:39:23.089-08:002015-02-10T07:39:23.089-08:00Yes, those mice were infected with lymphoma cells ...Yes, those mice were infected with lymphoma cells and this treatment showed delayed tumor growth. These mice, without treatment, would've died in 25 days. I should have included that, thank you for pointing that out! Also, I believe at this stage it's considered a treatment. Hopefully one day it can actually be used in humans. <br /><br />- Carolyn McDonaghAnonymousnoreply@blogger.comtag:blogger.com,1999:blog-9008122866340502585.post-18752073120578470852015-02-09T19:26:41.313-08:002015-02-09T19:26:41.313-08:00What a cool concept. I'm a bit confused about ...What a cool concept. I'm a bit confused about one bit of this though. When you say "90% of mice are still alive at 30 days", do you mean that all of said mice have terminal cancer and are on death row already? Is there any research showing cancer regression using this therapy, or is it more of a treatment, and less of a cure?<br /><br />~David AlmanzarAnonymousnoreply@blogger.com