A largest study was done in identifying four new genes that are linked to Alzheimer’s disease. Researchers from a consortium of 44 universities and research institutions in the United States, including Rush University Medical Center worked together in findings of new genes involved in developing risk for Alzheimer’s disease in which each gene is linked to the formation of dementia later in life.
In the study, the Alzheimer’s Disease Genetics Consortium contributed in analyzing more than 11,000 people with Alzheimer’s disease and also about same number of elderly people who have no symptoms of dementia. The Rush Alzheimer’s Disease Center contributed clinical and genomic data from more than 1,500 participants in the Rush Orders Study and the Rush Memory and Aging Project. Three other consortia conducted data from additional people. Over 54,000 of people were analyzed in this study. The four genes are confirmed that are involved with Alzheimer’s disease. These genes include MS4A, CD2AP, CD33 and EPHA1, which contribute to identifying and confirming other two genes, BIN1 and ABCA7. The gene for apolipoprotein E-e4, APOE0e4 has been identified over 15 years ago and is known to have largest effect on risk. Also, other genes including CR1, CLU, and BIN1 were found over past two years.
Identifying new genes has led to believe that it provides major clues about the causes of the disease, which is very critical information to the drug discovery. In addition, this study can help researchers find and understand the pathogenic mechanisms that are involved in the developing this disease, which takes place in the brain by destroying larger parts of the brain and causing complete loss of cognitive abilities before any symptoms appear.
Posted by Arpita Patel