Now researchers at UCLA, believe they have found a method with wich they can prevent the buildup of Alpha Synuclein; which they believe to be the primary cause of this disease. They have created a compound known referred to as "molecular tweezers" which, in animal models, broke up deposits of A.S, stopped their toxicity, and did all of this without affecting normal brain function or other cells. This "molecular tweezer", known by its lab name of CLR01 binds with the proteins associated with the "C" shape of A.S, and help break aggregations down.
The first animal testing was done in Zebra fish, due to their ease of genetic manipulability. Using fluorescent proteins, scientists tracked the progress of A.S and how its buildup affected the brain. Just as in cell cultures preformed prior to the live animal trial, CLR01 was successful in preventing A.S aggregation and neuronal death. Results look promising, and the group plans on moving on to trials in mice before moving on to human trials.
This is an incredible advance in the prevention and possible cure of Parkinson's. Although the trials have only been preformed on zebra fish and lab cultures, the results are astonishing. CLR01 has so far resulted in the prevention and ultimately the cure of Parkinson's in test trials. This creation's reach will extend far beyond the boundaries of Parkinson's, and will have implications for the whole field of neurodegenerative diseases. Alzheimer's, Parkinson's, and Huntington's Disease are all similar in terms of systemic problems, and this breakthrough could very well help cure more than just Parkinson's.
- Jeff Keating (2)