SEX DIFFERENCES in the GUT MICROBIOME DRIVE HORMONE-DEPENDENT REGULATION of AUTOIMMUNITY
Usually one is told to abstain from germs, however exposure to some germs and awareness of what one is at risk for depending on their sex can help them identify their resistance to Type 1 Diabetes. An individual’s susceptibility to autoimmune disease is caused both by environmental and genetic factors, but what is it about germs and whether one is a male or female that influences an individual’s susceptibility to autoimmunity? Is it safer to live in a germ- free environment or a non- germ- free environment? Do bacteria pose a mutualistic effect on a host metabolism?
According to a recent article, it has been shown that being a female and living in a germ- free environment increases ones chances of obtaining Type 1 diabetes. Several tests were performed that proved this. These tests show that because females have a different microbiome, they are more likely to get diabetes than a male. Furthermore, having a higher level of testosterone leads to a diminished likelihood of obtaining diabetes.
These tests are important because they help patients and doctors determine how great of a risk the patient is for diabetes and therefore having a plan implemented to prevent or treat the disease. Additionally, doctors and patients need to be aware in the early stages of life about this possibility because early- life exposure to microbiota determines levels of sex hormone which therefore effect one’s ability to protect against diabetes. Thanks to the current testing and research we can better regulate the fate of individuals with high genetic risk.
Posted by Marshall Moini (2)