SEX DIFFERENCES in the GUT MICROBIOME DRIVE HORMONE-DEPENDENT REGULATION of AUTOIMMUNITY
Usually one is told to abstain from germs, however exposure
to some germs and awareness of what one is at risk for depending on their sex
can help them identify their resistance to Type 1 Diabetes. An individual’s susceptibility
to autoimmune disease is caused both by environmental and genetic factors, but
what is it about germs and whether one is a male or female that influences an individual’s
susceptibility to autoimmunity? Is it safer to live in a germ- free environment
or a non- germ- free environment? Do bacteria pose a mutualistic effect on a
host metabolism?
According to a recent article, it has been shown that being
a female and living in a germ- free environment increases ones chances of
obtaining Type 1 diabetes. Several tests
were performed that proved this. These
tests show that because females have a different microbiome, they are more
likely to get diabetes than a male. Furthermore,
having a higher level of testosterone leads to a diminished likelihood of
obtaining diabetes.
These tests are important because they help patients and
doctors determine how great of a risk the patient is for diabetes and therefore
having a plan implemented to prevent or treat the disease. Additionally,
doctors and patients need to be aware in the early stages of life about this possibility
because early- life exposure to microbiota determines levels of sex hormone
which therefore effect one’s ability to protect against diabetes. Thanks to the
current testing and research we can better regulate the fate of individuals
with high genetic risk.
Posted by Marshall Moini (2)
So what would happen if you were a female and didn't live in a germ free environment? Would the risks for diabetes decrease?
ReplyDeleteKimberly Ty (3)
Do you think with higher estrogen levels and the fact that most of America is obese, that this is a lethal combination for diabetes type 1? And in the future, do you see a majority of females in the population having Diabetes?
ReplyDeleteCynthia Bui (1)
I was surprised to learn about the early-life exposure to microbiota affecting sex hormone levels. Did you learn how long this effect lasts? Sex hormones have a huge effect on a person's physical development, including in the brain. If the gut microbiome influences testoserone levels throughout a person's lifetime, or even has a role in the early organizational effect of testosterone/estrogens, there would be many implications beyond susceptibility to diabetes
ReplyDeleteJoseph Starrett (3)
how do they know that the risk is from being in a germ-free environment and is not from other reasons such as diet?
ReplyDeleteTonya Sulham (3)
Its interesting to see how a female living in a germ-free environment increases the chances of type 1 diabetes. I would have thought that diet plays an even greater role in the risk of developing diabetes since it tends to be more prevalent in obese people. Does this mean that an obese female living in a germ-free environment is at the highest risk possible for developing type 1 diabetes?
ReplyDeleteGabrielle Wertheim (3)
That is a good question to consider. The bacteria within the gut of obese individuals is different from that in the gut of an individual at a healthy weight. It would make sense that this different environment would influence testosterone levels and thus ones protection against T1D.
DeleteThis is really interesting because I thought that men and women were equally as likely to develop diabetes regardless of environment. I had no idea that early-life exposure to microbiota affects sex hormone levels. However, isn't living in a germ free environment nearly impossible?
ReplyDeleteLindsey Dugas (1)
Indeed it is interesting. But what we have to remember is that everything in this world needs to be in moderation. Too much or little of anything isn't good. But although women are at a higher risk for T1D we have to wonder if there will be treatments in the future to intentionally expose women to such bacteria to induce higher levels of immunity.
DeleteAre there other differences in susceptibility between men and women for different types of disease? Also, with this particular situation, does age of the patient when they contract T1D or come in contact with germs have an affect?
ReplyDeleteAshley Sterpka (1)
"Being a female and living in a germ- free environment increases one chances of obtaining Type 1 diabetes", so does this mean females from let's say,third world countries, are less prone to have T1D? Which country has the highest rate of the T1D?
ReplyDeleteIn general, the rate of males having diabetes are more than the rate of females with diabetes.
Setareh Sepasi (3)
My name is hoover, my 18 year old daughter, Tricia was diagnosed with herpes 3 years ago. Since then, we have moved from one hospital to another. We tried all kinds of pills, but every effort to get rid of the virus was futile. The bubbles continued to reappear after a few months. My daughter was using 200mg acyclovir pills. 2 tablets every 6 hours and 15g of fusitin cream. and H5 POT. Permanganate with water to be applied twice a day, but all still do not show results. So, I was on the internet a few months ago, to look for other ways to save my only son. Only then did I come across a comment about the herbal treatment of Dr Imoloa and decided to give it a try. I contacted him and he prepared some herbs and sent them, along with guidance on how to use them via the DHL courier service. my daughter used it as directed by dr imoloa and in less than 14 days, my daughter recovered her health. You should contact dr imoloa today directly at his email address for any type of health problem; lupus disease, mouth ulcer, mouth cancer, body pain, fever, hepatitis ABC, syphilis, diarrhea, HIV / AIDS, Huntington's disease, back acne, chronic kidney failure, addison's disease, chronic pain, Crohn's pain, cystic fibrosis, fibromyalgia, inflammatory Bowel disease, fungal nail disease, Lyme disease, Celia disease, Lymphoma, Major depression, Malignant melanoma, Mania, Melorheostosis, Meniere's disease, Mucopolysaccharidosis, Multiple sclerosis, Muscular dystrophy, Rheumatoid arthritis Alzheimer's disease, parkinson's disease, vaginal cancer, epilepsy Anxiety Disorders, Autoimmune Disease, Back Pain, Back Sprain, Bipolar Disorder, Brain Tumor, Malignant, Bruxism, Bulimia, Cervical Disc Disease, Cardiovascular Disease, Neoplasms , chronic respiratory disease, mental and behavioral disorder, Cystic Fibrosis, Hypertension, Diabetes, Asthma, Autoimmune inflammatory media arthritis ed. chronic kidney disease, inflammatory joint disease, impotence, alcohol spectrum feta, dysthymic disorder, eczema, tuberculosis, chronic fatigue syndrome, constipation, inflammatory bowel disease. and many more; contact him at drimolaherbalmademedicine@gmail.com./ also with whatssap- + 2347081986098.
ReplyDelete