Serotonin is a neurotransmitter commonly found in the central nervous system of humans and animals. Serotonin serves to control mood, appetite, and even sleep. In a study, conducted by Zhou-Feng Chen of Washington University School of Medicine in St. Louis, Chen genetically engineered male mice to lack serotonin producing brain cells. Chen observed the mating patterns of these mice and saw that they still went after female mice, like the control mice with serotonin producing brain cells. But when they were put with both a female mouse and a male mouse, 50 percent of these mice went after another male mouse, while the other 50 percent went after a female mouse. These serotonin male mice were also more likely, than the control mice, and try to serenade another male mouse, by giving off an ultrasonic squeak.
There is still a lot not known about this study. For example it is still not know how female mice would be effected if they were to lack serotonin. Also not known is how this would effect human beings. But if serotonin is a neurotransmitter, which effects human emotions, and is said to make people feel better, could taking away serotonin producing brain cells make someone almost, for lack of a better term, crazy?
http://www.sciencenews.org/view/generic/id/71586/title/Brain_chemical_influences_sexual_preference_in_mice
Thursday, March 24, 2011
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I am really interested in the methods and details of this study. If it is indeed true that serotonin makes most male mice heterosexual, and the lack of this neurotransmitter causes about half of male mice to be homosexual, then what would the lack of serotonin do to human males? I am very curious about this, but unsure whether this will ever be done willingly or unwillingly. I would also like to know if the mice genetically engineered to be without serotonin actually went "crazy." I would hope some tests like this could be done on other animals, but I am just as intrigued (and I am not sure why this was not done and published already) to find out the implications of doing this procedure on female mice. From now on, I think I am going to refer to Serotonin as the propagation neurotransmitter.
ReplyDeletePosted by Derek Melzar
This is very interesting article in knowing the role of serotonin and its effects on mice. The male mice behavior could be affected by the level of serotonin. There might be a relationship between the amount of serotonin and their behavior. Also, it would be interesting to know the effects of serotonin in females. Perhaps, female could get affected more than males or vice versa. I would like to see the trend between males and female mice.
ReplyDeleteArpita Patel
Since the results of the study showed a 50/50 preference of male mice to both sexes, it seems that serotonin may be linked to factors in sex determination in the male mice. In some social organisms serotonin is linked to dominance and the fight or flight response (more serotonin enhances dominance). Here dominance in males is obviously maintained without serotonin. Like you mentioned, it would be interesting to see how the opposite sex would be affected by the lack of serotonin. However, it would also interesting to see how both sexes would react to enhanced serotonin levels, it can possibly increase aggression.
ReplyDeletePosted by: Nelson Milano
I read this article somewhere else, in Science Daily, I think, and that article focused on the implications this study had for the effects of social isolation on sexual preference. Serotonin is also released in response to social stimulation, and is deficient in people who are clinically depressed. I guess one way to test this effect in humans is to assess how sexually attractive clinically depressed persons vs. a non-depressed control group find members of the same sex to be.
ReplyDeletePosted by Connor Finnerty
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ReplyDeleteCan we see same patterns of sexual preferences in humans as in mice. Indeed serotonin plays an important role in mood elevation but what is the exact relationship of serotonin and sexual preference?
ReplyDeleteby Ammar Zafar
Response-
ReplyDeleteDerek- The mice which lack serotonin don’t become homosexual, or stay heterosexual, they just don’t necessarily have a preference for a mate. In the study Chen put a mouse, which lacked serotonin, with a female mouse and it still made a move on her. It was just when he put the mouse in with both sexes that the mouse might have chosen the other male.
Arbita- I definitely think that female mice would be affected, kind of like the way the male mice was. I definitely don’t know how they are affected but I’m sure they aren’t the same without the neurotransmitter.
Nelson- Increasing serotonin levels would probably make the mice much more aggressive.
Ammar- I don’t think serotonin has any affect on the sexual preference of mice, I think it just makes them not really care about what sex the other mouse is.
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