A new breakthrough in cancer treatment has shown astonishing result in the treatment of blood cancer. T-Cell Therapy uses the body’s own immune system cells to attack tumors that have spread in in the body. T-Cells are a type of white blood cells that are engineered in the laboratory to identify and attack tumorous cells. Many scientist are testing many kind of T-Cell therapy using chimeric antigen receptor (CAR) T cells to target the disease.
Trials of CAR T cells in adults and children with leukemia and lymphoma have used T cells engineered to target the CD19 antigen, which is present on the surface of nearly all B cells, both normal and cancerous. Nineteen of the 27 patients with complete responses have remained in remission with 15 of these patients receiving no further therapy and 4 patients withdrawing from the trial to receive other therapy. According to the most recent data from a POB trial that included children with ALL, 14 of 20 patients had a complete response. And of the 12 patients who had no evidence of leukemic cells, called blasts, in their bone marrow after CAR T-cell treatment, 10 have gone on to receive a stem cell transplant and remain cancer free.
Even though the results of this therapy have been over all positive, the summary of results discussed at the American Association of the Advancement of Science annual meeting have not been published. There is still a debate of whether or not this is a therapy that should be provided to patients and the repercussions that this therapy may have. Some specialist urged caution over early trial of T-Cell therapy saying that some patients experienced toxic side effects. However, improvement has been seen in patients that have failed at other treatments.
Research are still being conducted to see more results of this therapies. But if this works, I wonder if these cells can be adapted to treat other cancers.
Yerkely Gomez (1)