Wednesday, March 23, 2011

Harvard's Cell `Makeover' May Spur Diabetes Therapy

Using biological alchemy, Harvard University researchers turned one type of cell found in the pancreas of mice into the variety that secretes the hormone insulin.

If the technique can be used safely in humans, one day it can treat diabetes, which occurs when the body either can't produce, or else makes too little of, the insulin needed to process blood sugar. The same approach might be used to make heart, brain, or liver cells from other existing cells and treat diseases in those organs, said a stem-cell scientist who wasn't involved in the findings.

The research team in Cambridge, Massachusetts. The scientists injected viruses bearing three genes into the mice, transforming a common pancreatic cell known as an exocrine cell into the much rarer beta cell that makes insulin. Their findings were published in the journal Nature.

Melton said he aims to refine the technique, show that it can be done safely, and begin human clinical trials within two to five years in diabetes patients.

``We were able to flip the cell from one state into another, what one of the younger students in my lab calls an extreme makeover,'' Melton said yesterday in a conference call with reporters.

The Harvard researchers are calling the process direct reprogramming.

The research says that every cell in a person or animal contains DNA with the complete set of genetic instructions required to create that individual. By turning select genes on and off, scientists can transform existing cells so they start looking and acting like others.

Melton and his team spent three years searching for so- called transcription factors, which control proteins that in turn switch other genes on and off. They started with 1,100 candidate genes and narrowed the field to 28 that are involved in forming the part of the pancreas where beta cells are found.

Finally, they settled on nine genes they guessed might be involved and began a trial-and-error process, injecting them into the pancreases of mice and eliminating one at a time. Finally, they found that just three genes were needed and that 20 percent of the exocrine cells they injected turned into beta cells.


Cleopatra Duque


30 comments:

  1. I am curious whether the injected cells are stem cells in which gene expression is much easier to control than adult somatic cells. If this is true, not only is the actual level of future success in diabetic treatment a problem, but the use of stem cells will also become an issue since this is a very debated topic. In my opinion, this study looks very promising and I hope it progresses to eventually a cure for diabetes.

    Posted by Marlena Grasso

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  2. Cleopatra,

    This is a very well-written post. The explanations are helpful but avoid the traps of condescension or over-explanation--nice job.

    ---

    On the surface, this idea of direct reprogramming seems like a scientific leap forward and a new sign of hope for the ever-increasing number of people suffering from diabetes.

    One of the real problems, though, is the issue of insuring that the cells fulfill their intended function. When it comes to this, there has always been concerns of injected cells becoming cancerous. Even though this risk is small, it's not one that any clinician should take lightly; a mistake could easily cost someone their life.

    It seems that the researchers recognize the possibilities without belittling the risks, but, in all sincerity, is there actually a set date to begin the very, very long process of clinical trials?


    Posted by: Alexander Simolaris

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  3. I wonder if this will be applicable to all people who have diabetes or if it will apply to only one type. What were the results of the mice that had this process done? Were they able to process their blood sugar correctly? I am also curious of the long term affects that these beta cells could have on the pancreas or other organs.

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  4. i honestly think it is amazing how our society has so much research going on right now. it was so hard for me to choose one research to write about. But i think because diabetes is such a big disease and this specific researcher has kids with it the passion for a cure is so great since it has a personal level to it.

    personally i think this is a crazy idea. but crazy ideas often change the world.


    Cleopatra Duque

    ReplyDelete
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  16. Greatest thanks to Dr Oyagu for his herbal drugs that he prepared for me and when i start using it in just 2weeks i was completely cured and that ended my HERPES SIMPLEX 1&2 DISEASE i am so happy and grateful to Dr Oyagu . after reading about him on a testimony of Jason Cash on a blogger. i knew suddenly Dr Oyagu was the right Doctor to cure my HERPES SIMPLEX 1&2 DISEASE. i discuss with Dr Oyagu and he prepared a herbal medicine for me and when it got sent to me in south korean . i used the herbal medicine and 2weeks and i went to check up again. after 15years of suffering from HERPES SIMPLEX 1&2 at last i am smiling once again. Dr Oyagu also has remedy to others disease like COLD SORES,HIV/AIDS,DIABETES.CANCER,HIGH BLOOD PRESSURE AND MANY MORE. I oblige everyone to contact this powerful herbalist Dr Oyagu and be free from your suffering. contact his WhatsApp line:+2348101755322 or his Email:Oyaguherbalhome@gmail.com

    ReplyDelete
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    ReplyDelete
  18. i got hpv from my boyfriend  and i was trying all i could do to get rid of this virus over 4 months now i have taking a lot of drugs from different medical doctor which didn't work at all, last month i was doing some research on google on how to get cured totally from this virus i found someone testimony on how she got cured totally from hpv with the help of doc. onokun  natural herbs and she drop doc onokun email address, So i decide to give him a try and i contact him for help he told how to purchase the natural herbs and i did that, Do you believe i only took this herbs for 2 weeks and i got cured permanently from the hpv virus without no side effect. Thank you so much doc onokun for the help i will make sure i tell the whole world about you. contact him if you need his help too  via: Dronokunherbalcure@gmail.com 

    ReplyDelete
  19. i got hpv from my boyfriend  and i was trying all i could do to get rid of this virus over 4 months now i have taking a lot of drugs from different medical doctor which didn't work at all, last month i was doing some research on google on how to get cured totally from this virus i found someone testimony on how she got cured totally from hpv with the help of doc. onokun  natural herbs and she drop doc onokun email address, So i decide to give him a try and i contact him for help he told how to purchase the natural herbs and i did that, Do you believe i only took this herbs for 2 weeks and i got cured permanently from the hpv virus without no side effect. Thank you so much doc onokun for the help i will make sure i tell the whole world about you. contact him if you need his help too  via: Dronokunherbalcure@gmail.com 

    ReplyDelete
  20. I found out, that taking herbal treatment is the best to get rid of (HPV) as soon as i feel the symptoms of (HPV) is appearing, i took the healing process by contacting Dr LUCKY  for natural treatment it works wonders, amazingly ever since I had the herbal treatment i have not feel these horrible disease anymore and my doc told me the virus is gone, i am glad i finally got cured out from this horrible disease. every (HPV) or herpes patients should also get in touch with this herbalist Dr to get ride of these disease forever his email address;  (drluckyherbalcure@gmail.com)

    ReplyDelete
  21. Greatest thanks to Dr Alika for his herbal drugs that he prepared for me and when i start using it in just 14days i was completely cured and that ended my HERPES DISEASE i am so happy and grateful to Dr Alika . after reading about him on a testimony of Jason Cash on a blogger. i knew suddenly Dr Alika was the right Doctor to cure my HERPES DISEASE. i discuss with Dr Alika and he prepared a herbal medicine for me and when it got sent to me in usa . i used the herbal medicine and 14days and i went to check up again. after 15years of suffering from HERPES VIRUS at last i am smiling once again. Dr Alika also has remedy to others disease like COLD,HERPES,SORES,HIV/AIDS,DIABETES.CANCER,HIGH BLOOD PRESSURE AND MANY MORE. I oblige everyone to contact this powerful herbalist Dr Alika and be free from your suffering. contact his WhatsApp line:+2348116570358 or his Email via dralikaherbalhome@gmail.com

    ReplyDelete
  22. Greatest thanks to Dr Alika for his herbal drugs that he prepared for me and when i start using it in just 14days i was completely cured and that ended my HERPES DISEASE i am so happy and grateful to Dr Alika . after reading about him on a testimony of Jason Cash on a blogger. i knew suddenly Dr Alika was the right Doctor to cure my HERPES DISEASE. i discuss with Dr Alika and he prepared a herbal medicine for me and when it got sent to me in usa . i used the herbal medicine and 14days and i went to check up again. after 15years of suffering from HERPES VIRUS at last i am smiling once again. Dr Alika also has remedy to others disease like COLD,HERPES,SORES,HIV/AIDS,DIABETES.CANCER,HIGH BLOOD PRESSURE AND MANY MORE. I oblige everyone to contact this powerful herbalist Dr Alika and be free from your suffering. contact his WhatsApp line:+2348116570358 or his Email via dralikaherbalhome@gmail.com

    ReplyDelete
  23. HELLO EVERYONE.. FEW MUNINETS TO REDY THIS INFOR ON HERPES CURE 2018..
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    ReplyDelete
  24. HELLO EVERYONE.. FEW MUNINETS TO REDY THIS INFOR ON HERPES CURE 2018..
    2017 MY MOTHER WAS DIAGNOSED OF HERPES/ KNOWN AS GENITAL WARTS ,I SPENT A LOT OF MONEY ON HER MEDICATION TILL A POINT I EVEN LOST HOPE,BECAUSE MY MOTHER WAS GRADUALLY DYING AND LOST HER MEMORY TOO, I WAS SO DESPERATE TO GET MY MOTHER BACK TO NORMAL, ONE DAY MY UNCLE WHO LIVES IN LONDON UNITED KINGDOM TOLD ME ABOUT DR OLIHA ,WHO HELPED HIM GET RID OF HERPES /GENITAL WART WITH HERBAL MEDICINE AND HIS HERBAL SOAP ,I WAS SO SHOCKED WHEN HE TOLD ME ABOUT THIS ,ALTHOUGH I NEVER BELIEVE IN HERB BUT, I KEEP TO BELIEVE BECAUSE MY UNCLE CAN'T TELL ME LIES WHEN IT COMES TO HEALTH CONDITION I CONTACTED DR OLIHA VIA HIS EMAIL; OLIHA.MIRACLEMEDICINE@GMAIL.COM , YOU CAN TALK TO HIM VIA CALL OR WHATSAPP MESSENGER ON +2349038382931 , HE REPLIED AND ASK ME TO SEND MY HOME ADDRESS AND MY MOTHER'S DETAIL AND THEN I PURCHASED THE HERBAL MEDICINE,SENT ME THE HERBAL MEDICINE THROUGH COURIER SERVICE, WHEN I RECEIVED THIS HERBAL MEDICINE USED IT FOR 2 WEEKS, AND 4 DAYS OF USAGE THE WARTS FELL OFF, MY MOTHER I NOW TOTALLY CURED AND MY MOTHER IS LIVING FREE AND HAPPY AGAIN. YOU CAN TALK TO DR VIA HIS MOBILE NUMBER OR WHATS APP HIM ON +2349038382931.ALL THANKS TO DOCTOR DR OLIHA

    ReplyDelete
  25. I'm 61 years old, I contracted hpv in 2011' I has be taking lot treatment for it and embarrassed some months ago the wart stated coming out seriously, I used lot recommendation because there was lot warts around my anus and was so . but today I'm totally happy I got the virus eliminated by using natural treatment from Dr Onokun herbal center after his treatment I got cured. all the warts went away' seriously believed Dr Onokun he have the cure for human papillomavirus because he has eliminated hpv been in my body since 2011, Dr Onokun make it possible for me. Here is Dr Onokun email:  dronokunherbalcure@gmail.com 

    ReplyDelete
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    ReplyDelete
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    ReplyDelete
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    ReplyDelete
  29. I contracted hpv from my ex partner we broke up the relationship about four years ago, I has been on treatment for some years, I had lot pains and embarrassment for been hpv patient last two month i did hpv research online and found website for natural treatment to get ride of my infection, and i went through the site and recommend me to Dr onokun I contacted Dr onokun through his website and been his patient after one month I got cured. I want everyone living with hpv to get this treatment and got cured Dr onokun have the cure to every virus. his email; Dronokunherbalcure@gmail.com or website: https:// Dronokunherbalcure.wordpress.com/

    ReplyDelete
  30. i have been suffering from a deadly disease (Hsv) for the past 3 years now, I had spent a lIot of money going from one places to another, from churches to churches, hospitals have been my home every day residence. Constant checks up have been my hobby not until this faithful day, I was searching through the internet, I saw a testimony on how Dr Onokun helped someone in curing his (Hsv) herpes disease, quickly I copied his email which is Dronokunherbalcure@gmail.com just to give him a test I spoke to him, he asked me to do some certain things which I did, he told me that he is going to provide the herbal cure to me, which he did, then he asked me to go for medical checkup after some days after using the herbal cure, behold I was free from the deadly disease, he only asked me to post the testimony through the whole world, faithfully am doing it now, please brothers and sisters, he is great, I owe him in return. if you are having a similar problem just email him on : Dronokunherbalcure@gmail.com

    ReplyDelete