Thursday, March 3, 2011

New connection in cancer treatment.

Researchers have made an interesting find in the area of cancer research recently. Two different studies each independently provided a link between the FBW7 gene and a resistance to treatment with chemotherapy drugs that focus on tubulin to kill cancerous cells, such as Taxol. Tubulin is a protein which is integral in the network of filaments that maintains the cells infrastructure. Cells which are affected by anti-tubulin drugs cannot divide and eventually die without causing further spread of cancerous cell lines. However, many cells display a resistance to the affects of the anti-tubulin drugs. Which prompted some researchers to ask 'why?'.


One of the research projects that made the connection to FBW7 and this resistance was lead by Ingrid Wertz, this was prompted by the observation that some cells resist Taxol treatment. Wertz and her team noticed a trend that cells which had survived treatment had lower levels of MCL1, a protein associated with the cell's life cycle. Further observation revealed FBW7 was found to be destroying MCL1 in these cell, FBW7 was already known to be a cancer-fighting element in cells. Speculation was that defects in FBW7 may result in higher levels of MCL1 which allowed cells to resist treatment by anti-tubulin drugs. Sure enough, researchers soon found the link between these two proteins.


Another project, headed by Wenyi Wei was focused on researching a particular disease: T-cell acute lymphoblastic leukemia. With this disease, cells have a cocktail of proteins that should cause them to self-destruct but do not do so. Researchers looked into why this occurred and found that these cells lacked the FBW7 gene and without this, they did not break down MCL1 which was a necessary step in cell death. Wei connected this to drug resistance when T-ALL cells that were treated with drugs that targeted cell survivability-pathways were found to have lowered levels of MCL1 also. To try to fix this, Wei treated the cells with a drug that lowered MCL1 drugs and restored sensitivity to treatment.


While exciting in the prospect that oncologists now have insight into reasons why patients may be feeling less many experts in the field are quick to note that these results are only preliminary. They provide just a small glimpse at the bigger picture of cancer treatment. Research has shown only one implication of defects in the FBW7 gene, many other details may lie further downstream in the regulation of cell growth and death. But this is surely a good step for better, more effective cancer treatment.


-Phillip Hunt

25 comments:

  1. This article has a beginning step of treating cancer. It is very stimulating that the researchers have found one beginning step to lead them further to research on treating the cancer. It will be great and very helpful in saving many lives suffering from cancer.

    Posted by Arpita Patel

    ReplyDelete
  2. Reseachers are researching on cancer for so many years and as time goes by, they are coming with better ideas to treat cancer, in terms to help both doctors and patients. I am sure that in coming years scientists and researchers will make cancer treatment more easier with the help of technology.

    by Ammar Zafar

    ReplyDelete
  3. 5 years ago I had warts, I was treated with some liquid applied to the warts they continued to grow and spread... The next 2 doctors did laser surgery to remove them. 1 year after the surgery, they grew back close to where the 1st ones were' so I was finally told it was hpv. I have had it for very long time, I contract it from my cheated boyfriend and I found out he was also infected and I end up the relationship between us. the warts was so embarrasses because it started spreading all over I have be dealing with this things for very long time the last treatment I take was About 2 years ago I applied natural treatment from Dr onokun herbal cure, a week after applying the treatment all the warts was gone. it's now 2 years and some months I don't have single wart or any symptoms of hpv. wow"" it's great, Dr onokun has finally cured me. Anyone living with hpv contact Dr onokun for natural treatment.
    His email address: dronokunherbalcure@gmail.com‎

    ReplyDelete
  4. 5 years ago I had warts, I was treated with some liquid applied to the warts they continued to grow and spread... The next 2 doctors did laser surgery to remove them. 1 year after the surgery, they grew back close to where the 1st ones were' so I was finally told it was hpv. I have had it for very long time, I contract it from my cheated boyfriend and I found out he was also infected and I end up the relationship between us. the warts was so embarrasses because it started spreading all over I have be dealing with this things for very long time the last treatment I take was About 2 years ago I applied natural treatment from Dr onokun herbal cure, a week after applying the treatment all the warts was gone. it's now 2 years and some months I don't have single wart or any symptoms of hpv. wow"" it's great, Dr onokun has finally cured me. Anyone living with hpv contact Dr onokun for natural treatment.
    His email address: dronokunherbalcure@gmail.com‎

    ReplyDelete
  5. i was diagnose with genital warts,last six months which finally shows out! i had hpv. for very long time i suffered for the virus and i was told there is no hpv cure. except treatment to control it i just fill killing my self because there was no hope all i could think loosing my life because it was so embarrass for been hpv patient. about few weeks ago i read possible natural cure on line which was guarantee and i purchased it. after two weeks taking herbal treatment the hpv got eliminated by killing all symptoms and the warts in my genital area disappeared. it so amazing i got ride to the hpv. i so much like to shear this testimony to every article for others living with hpv there is possible natural herbs to eliminate it. email Dr onokun for help. his herbal clinic address; dronokunherbalcure@gmail.com

    ReplyDelete
  6. 2 WEEKS AGO I ENDED NATURAL HERBAL TREATMENT FROM TRADITIONAL HEALER WHO IS IN AFRICAN, I GOT RID OF HPV VIRUS OUT OF MY BODY WITH HIS HERBAL TREATMENT. It SO AMAZING I'M FREE FROM THIS VIRUS FOREVER. YOU CAN REACH HIM ON; DRONOKUNHERBALCURE@GMAIL.COM

    ReplyDelete
  7. I was diagnose with human papilloma virus (HPV) 4 years ago and i met a doctor he told me there is no cure and i have be taking some medication the warts multiplied when trying to removed them and it got me embarrass and pains, luckily few weeks ago i was recommend to Dr Onokun for natural treatment after one week i got 100% cure and all the wart and pains got disappeared, i sheared this post because its part of my life experience, encase anyone need speedy help about this cure email Dr Onokun via, dronokunherbalcure@gmail.com

    ReplyDelete
  8. I Want To Appreciate Dr.OYAGU for hs great deeds, I Was Diagnosed With type 2 Herpes Virus Last year,And Was Look For Solution To Be Cured Luckily I Saw Testimonies On How Dr.OYAGU Cure Herpes Virus I Decided To Contact Dr.OYAGU I Contacted Him He Prepared A Herbal Medicine Portion And Sent It To Me,I Started The Herbal Medicine For My Health.He Gave Me Step By Step Instructions On How To Apply It, When I Applied It As Instructed, I Was Cured Of This Deadly Herpes Within 2 weeks, I Am Now Herpes Negative.My Brother And Sister I No That There Are So Many People That Have There Same Herpes Virus Please contact Dr OYAGU To Help You Too,And Help Me To Thank Dr.OYAGU For Cure Me, I’m Cured By Dr. OYAGU Herbal Medicine,His Contact Email:oyaguspellcaster@gmail.com

    Or Cell Whatsapp Number +2348101755322 thank you .....

    ReplyDelete
  9. I'm 61 years old, I contracted hpv in 2011' I has be taking lot treatment for it and embarrassedsome months ago the wart stated coming out seriously, I used lot recommendation because there was lot warts around my anus and was so . but today I'm totally happy I got the virus eliminated by using natural treatment from Dr Onokun herbal center after his treatment I got cured. all the warts went away' seriously believed Dr Onokun he have the cure for human papillomavirus because he has eliminated hpv been in my body since 2011, Dr Onokun make it possible for me. Here is Dr Onokun email to reach him: Dronokunherbalcure@gmail.com  he is welled capable of curing terrible diseases.  

    ReplyDelete
  10. I Want To Appreciate Dr.OYAGU for hs great deeds, I Was Diagnosed With type 2 Herpes Virus Last year,And Was Look For Solution To Be Cured Luckily I Saw Testimonies On How Dr.OYAGU Cure Herpes Virus I Decided To Contact Dr.OYAGU I Contacted Him He Prepared A Herbal Medicine Portion And Sent It To Me,I Started The Herbal Medicine For My Health.He Gave Me Step By Step Instructions On How To Apply It, When I Applied It As Instructed, I Was Cured Of This Deadly Herpes Within 2 weeks, I Am Now Herpes Negative.My Brother And Sister I No That There Are So Many People That Have There Same Herpes Virus Please contact Dr OYAGU To Help You Too,And Help Me To Thank Dr.OYAGU For Cure Me, I’m Cured By Dr. OYAGU Herbal Medicine,His Contact Email:oyaguspellcaster@gmail.com

    Or Cell Whatsapp Number +2348101755322 thank you .....

    ReplyDelete
  11. I Want To Appreciate Dr.OYAGU for hs great deeds, I Was Diagnosed With type 2 Herpes Virus Last year,And Was Look For Solution To Be Cured Luckily I Saw Testimonies On How Dr.OYAGU Cure Herpes Virus I Decided To Contact Dr.OYAGU I Contacted Him He Prepared A Herbal Medicine Portion And Sent It To Me,I Started The Herbal Medicine For My Health.He Gave Me Step By Step Instructions On How To Apply It, When I Applied It As Instructed, I Was Cured Of This Deadly Herpes Within 2 weeks, I Am Now Herpes Negative.My Brother And Sister I No That There Are So Many People That Have There Same Herpes Virus Please contact Dr OYAGU To Help You Too,And Help Me To Thank Dr.OYAGU For Cure Me, I’m Cured By Dr. OYAGU Herbal Medicine,His Contact Email:oyaguspellcaster@gmail.com

    Or Cell Whatsapp Number +2348101755322 thank you .....

    ReplyDelete
  12. I Want To Appreciate Dr.OYAGU for hs great deeds, I Was Diagnosed With type 2 Herpes Virus Last year,And Was Look For Solution To Be Cured Luckily I Saw Testimonies On How Dr.OYAGU Cure Herpes Virus I Decided To Contact Dr.OYAGU I Contacted Him He Prepared A Herbal Medicine Portion And Sent It To Me,I Started The Herbal Medicine For My Health.He Gave Me Step By Step Instructions On How To Apply It, When I Applied It As Instructed, I Was Cured Of This Deadly Herpes Within 2 weeks, I Am Now Herpes Negative.My Brother And Sister I No That There Are So Many People That Have There Same Herpes Virus Please contact Dr OYAGU To Help You Too,And Help Me To Thank Dr.OYAGU For Cure Me, I’m Cured By Dr. OYAGU Herbal Medicine,His Contact Email:oyaguspellcaster@gmail.com

    Or Cell Whatsapp Number +2348101755322 thank you .....

    ReplyDelete
  13. Greatest thanks to Dr Oyagu for his herbal drugs that he prepared for me and when i start using it in just 2weeks i was completely cured and that ended my HERPES SIMPLEX 1&2 DISEASE i am so happy and grateful to Dr Oyagu . after reading about him on a testimony of Jason Cash on a blogger. i knew suddenly Dr Oyagu was the right Doctor to cure my HERPES SIMPLEX 1&2 DISEASE. i discuss with Dr Oyagu and he prepared a herbal medicine for me and when it got sent to me in south korean . i used the herbal medicine and 2weeks and i went to check up again. after 15years of suffering from HERPES SIMPLEX 1&2 at last i am smiling once again. Dr Oyagu also has remedy to others disease like COLD SORES,HIV/AIDS,DIABETES.CANCER,HIGH BLOOD PRESSURE AND MANY MORE. I oblige everyone to contact this powerful herbalist Dr Oyagu and be free from your suffering. contact his WhatsApp line:+2348101755322 or his Email:Oyaguspellcaster@gmail.com

    ReplyDelete
  14. I Want To Appreciate Dr.OYAGU for hs great deeds, I Was Diagnosed With type 2 Herpes Virus Last year,And Was Looking For Solution To Be Cured Luckily I Saw Testimonies On How Dr.OYAGU Cure Herpes Virus I Decided To Contact Dr.OYAGU I Contacted Him He Prepared A Herbal Medicine Portion And Sent It To Me,I Started The Herbal Medicine For My Health.He Gave Me Step By Step Instructions On How To Apply It, When I Applied It As Instructed, I Was Cured Of This Deadly Herpes Within 2 weeks, I Am Now Herpes Negative.My Brother And Sister I No That There Are So Many People That Have There Same Herpes Virus Please contact Dr OYAGU To Help You Too,And Help Me To Thank Dr.OYAGU For Cure Me, I’m Cured By Dr. OYAGU Herbal Medicine,His Contact Email:oyaguspellcaster@gmail.com

    Or Cell Whatsapp Number +2348101755322 thank you .....

    ReplyDelete
  15. Greatest thanks to Dr Oyagu for his herbal drugs that he prepared for me and when i start using it in just 2weeks i was completely cured and that ended my HERPES SIMPLEX 1&2 DISEASE i am so happy and grateful to Dr Oyagu . after reading about him on a testimony of Jason Cash on a blogger. i knew suddenly Dr Oyagu was the right Doctor to cure my HERPES SIMPLEX 1&2 DISEASE. i discuss with Dr Oyagu and he prepared a herbal medicine for me and when it got sent to me in south korean . i used the herbal medicine and 2weeks and i went to check up again. after 15years of suffering from HERPES SIMPLEX 1&2 at last i am smiling once again. Dr Oyagu also has remedy to others disease like COLD SORES,HIV/AIDS,DIABETES.CANCER,HIGH BLOOD PRESSURE AND MANY MORE. I oblige everyone to contact this powerful herbalist Dr Oyagu and be free from your suffering. contact his WhatsApp line:+2348101755322 or his Email:Oyaguherbalhome@gmail.com

    ReplyDelete
  16. I was diagnose with genital warts since 2013 i have be taking lot treatment and all i got is outbreak. in 2016 I gave up the treatment because I can't continues wasting time and money on treatment at the end it will not cure me. about 6 weeks ago i did natural research online I had So many people talking good about natural remedy, after the research i was recommended to Dr Lucky, And I wrote to him through his email and told him my problem after some conversations with him he gave me natural treatment after 1 week Dr Lucky btreated me i got cured permanently. and i went to see my doc he confirmed that the diseases has gone out from my body. every patients should know there is 100% natural hpv cure. contact Dr Lucky his email address: {drluckyherbalcure@gmail.com} or WHATSAPP HIM VIA
    +2348154637647

    ReplyDelete
  17. i got hpv from my boyfriend  and i was trying all i could do to get rid of this virus over 4 months now i have taking a lot of drugs from different medical doctor which didn't work at all, last month i was doing some research on google on how to get cured totally from this virus i found someone testimony on how she got cured totally from hpv with the help of doc. onokun  natural herbs and she drop doc onokun email address, So i decide to give him a try and i contact him for help he told how to purchase the natural herbs and i did that, Do you believe i only took this herbs for 2 weeks and i got cured permanently from the hpv virus without no side effect. Thank you so much doc onokun for the help i will make sure i tell the whole world about you. contact him if you need his help too  via: Dronokunherbalcure@gmail.com 

    ReplyDelete
  18. I found out, that taking herbal treatment is the best to get rid of (HPV) as soon as i feel the symptoms of (HPV) is appearing, i took the healing process by contacting Dr LUCKY  for natural treatment it works wonders, amazingly ever since I had the herbal treatment i have not feel these horrible disease anymore and my doc told me the virus is gone, i am glad i finally got cured out from this horrible disease. every (HPV) or herpes patients should also get in touch with this herbalist Dr to get ride of these disease forever his email address;  (drluckyherbalcure@gmail.com)

    ReplyDelete
  19. Greatest thanks to Dr Oyagu for his herbal drugs that he prepared for me and when i start using it in just 2weeks i was completely cured and that ended my HERPES SIMPLEX 1&2 DISEASE i am so happy and grateful to Dr Oyagu . after reading about him on a testimony of Jason Cash on a blogger. i knew suddenly Dr Oyagu was the right Doctor to cure my HERPES SIMPLEX 1&2 DISEASE. i discuss with Dr Oyagu and he prepared a herbal medicine for me and when it got sent to me in south korean . i used the herbal medicine and 2weeks and i went to check up again. after 15years of suffering from HERPES SIMPLEX 1&2 at last i am smiling once again. Dr Oyagu also has remedy to others disease like COLD SORES,HIV/AIDS,DIABETES.CANCER,HIGH BLOOD PRESSURE AND MANY MORE. I oblige everyone to contact this powerful herbalist Dr Oyagu and be free from your suffering. contact his WhatsApp line: +2348101755322 or his Email:Oyaguherbalhome@gmail.com

    ReplyDelete
  20. Quick Cure By Dr Alika 
    Joy and happiness is all i can see around me  ever since i came in contact with this great man dr alika. i complained bitterly to him about me having herpes only for him to tell me it’s a minor stuff. He told me he has cured thousands of people but i did not believe until he sent me the herbal medicine and i took it as instructed by this great man, then after taking the herbal medicine for 14days on the 15th day i went to the hodpital for test and i was confirmed negative. For the first time in four[4]years i was getting that result. i want to use this medium to thank this great man Dr Alika, i came in contact with his email through a friend  and ever since then my live has been full with laughter and great peace of mind. i urge you all with herpes or HSV to contact him if you willing to give him a chance. you can contact him through this email;dralikaherbalhome@gmail.com or you can also WhatsApp him +2348116570358

    ReplyDelete
  21. Greatest thanks to Dr Oyagu for his herbal drugs that he prepared for me and when i start using it in just 2weeks i was completely cured and that ended my HERPES SIMPLEX 1&2 DISEASE i am so happy and grateful to Dr Oyagu . after reading about him on a testimony of Jason Cash on a blogger. i knew suddenly Dr Oyagu was the right Doctor to cure my HERPES SIMPLEX 1&2 DISEASE. i discuss with Dr Oyagu and he prepared a herbal medicine for me and when it got sent to me in south korean . i used the herbal medicine and 2weeks and i went to check up again. after 15years of suffering from HERPES SIMPLEX 1&2 at last i am smiling once again. Dr Oyagu also has remedy to others disease like COLD SORES,HIV/AIDS,DIABETES.CANCER,HIGH BLOOD PRESSURE AND MANY MORE. I oblige everyone to contact this powerful herbalist Dr Oyagu and be free from your suffering. contact his WhatsApp line: +2348101755322 or his Email:Oyaguherbalhome@gmail.com

    ReplyDelete
  22. HELLO EVERYONE.. FEW MUNINETS TO REDY THIS INFOR ON HERPES CURE 2018..
    2017 MY MOTHER WAS DIAGNOSED OF HERPES/ KNOWN AS GENITAL WARTS ,I SPENT A LOT OF MONEY ON HER MEDICATION TILL A POINT I EVEN LOST HOPE,BECAUSE MY MOTHER WAS GRADUALLY DYING AND LOST HER MEMORY TOO, I WAS SO DESPERATE TO GET MY MOTHER BACK TO NORMAL, ONE DAY MY UNCLE WHO LIVES IN LONDON UNITED KINGDOM TOLD ME ABOUT DR OLIHA ,WHO HELPED HIM GET RID OF HERPES /GENITAL WART WITH HERBAL MEDICINE AND HIS HERBAL SOAP ,I WAS SO SHOCKED WHEN HE TOLD ME ABOUT THIS ,ALTHOUGH I NEVER BELIEVE IN HERB BUT, I KEEP TO BELIEVE BECAUSE MY UNCLE CAN'T TELL ME LIES WHEN IT COMES TO HEALTH CONDITION I CONTACTED DR OLIHA VIA HIS EMAIL; OLIHA.MIRACLEMEDICINE@GMAIL.COM , YOU CAN TALK TO HIM VIA CALL OR WHATSAPP MESSENGER ON +2349038382931 , HE REPLIED AND ASK ME TO SEND MY HOME ADDRESS AND MY MOTHER'S DETAIL AND THEN I PURCHASED THE HERBAL MEDICINE,SENT ME THE HERBAL MEDICINE THROUGH COURIER SERVICE, WHEN I RECEIVED THIS HERBAL MEDICINE USED IT FOR 2 WEEKS, AND 4 DAYS OF USAGE THE WARTS FELL OFF, MY MOTHER I NOW TOTALLY CURED AND MY MOTHER IS LIVING FREE AND HAPPY AGAIN. YOU CAN TALK TO DR VIA HIS MOBILE NUMBER OR WHATS APP HIM ON +2349038382931.ALL THANKS TO DOCTOR DR OLIHA

    ReplyDelete
  23. I'm 61 years old, I contracted hpv in 2011' I has be taking lot treatment for it and embarrassed some months ago the wart stated coming out seriously, I used lot recommendation because there was lot warts around my anus and was so . but today I'm totally happy I got the virus eliminated by using natural treatment from Dr Onokun herbal center after his treatment I got cured. all the warts went away' seriously believed Dr Onokun he have the cure for human papillomavirus because he has eliminated hpv been in my body since 2011, Dr Onokun make it possible for me. Here is Dr Onokun email:  dronokunherbalcure@gmail.com 

    ReplyDelete
  24. I'm Celina Gomez from Canada, i have been cured from genital herpes with herbalist Sakura herbal Remedy.
    i have been infected with genital herpes for 1 years now , i have done so many medical treatment from different hospital still
    not cured. On a very good day , i decided to make a research on my computer on how to get rid of genital herpes,i found a post of Sarah Wilson on how she was  cured from herpes with herbalist Dr sakura  herbal remedy.
    The Herbalist email/contact number  was there as well dr.sakuraspellalter@gmail.com/ +2348160802189. i contacted him because of my illness .He needed few of my information which i did, and also send me his medicine through FedEx courier service.
    which i received  after 3 working  days of shipment,i drink the  herbal medicine the same way Herbalist Dr Sakura instructed me too.but now my genital herpes is gone totally without any side effect or harm, may God Almighty continuing to bless him abundantly .
    you can contact him on mail/whats app dr.sakuraspellalter@gmail.com +2348110114739 or follow him on Instagram @Herbalist_sakura .you can also mail me for more information celinagomez784@gmail.com

    ReplyDelete
  25. Get traditional healing herbs to treat all kinds of ailments such as herpes, HPV, Cancer, Diabetes, Hepatitis etc.... whatsApp him on +2348110492548, droloriherbalcenter@gmail.com.



    Get traditional healing herbs to treat all kinds of ailments such as herpes, HPV, Cancer, Diabetes, Hepatitis etc.... whatsApp him on +2348110492548, droloriherbalcenter@gmail.com.




    Get traditional healing herbs to treat all kinds of ailments such as herpes, HPV, Cancer, Diabetes, Hepatitis etc.... whatsApp him on +2348110492548, droloriherbalcenter@gmail.com.




    Get traditional healing herbs to treat all kinds of ailments such as herpes, HPV, Cancer, Diabetes, Hepatitis etc.... whatsApp him on +2348110492548, droloriherbalcenter@gmail.com.

    ReplyDelete